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Novak Djokovic defeated the two-time defending champion Andy Murray in the final, 5–7, 7–6(13–11), 6–3 to win the singles tennis title at the 2012 Shanghai Masters. Djokovic saved five championship points en route to the title (all in the second set), and ended Murray's perfect 12–0 record at the event. The final was voted as the best ATP World Tour match of the 2012 season.
Seeds
The top eight seeds receive a bye into the second round.