Butaperazine

In this article, we will explore the issue of Butaperazine in depth, addressing its main aspects, implications and possible solutions. We will delve into its historical origin, as well as its relevance today, analyzing the different perspectives that exist on the matter. Likewise, we will examine the challenges and opportunities that Butaperazine poses in various areas, whether personal, social, economic, political or cultural. Through a multidisciplinary approach, we aim to offer a comprehensive and updated vision of Butaperazine, in order to encourage reflection and informed debate around this topic of great relevance in contemporary society.
Butaperazine
Clinical data
ATC code
Legal status
Legal status
  • BR: Class C1 (Other controlled substances)
Identifiers
  • 1-phenothiazin-2-yl]butan-1-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.010.450 Edit this at Wikidata
Chemical and physical data
FormulaC24H31N3OS
Molar mass409.59 g·mol−1
3D model (JSmol)
  • O=C(c2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(C)CC4)CCC
  • InChI=1S/C24H31N3OS/c1-3-7-22(28)19-10-11-24-21(18-19)27(20-8-4-5-9-23(20)29-24)13-6-12-26-16-14-25(2)15-17-26/h4-5,8-11,18H,3,6-7,12-17H2,1-2H3 checkY
  • Key:DVLBYTMYSMAKHP-UHFFFAOYSA-N checkY
  (verify)

Butaperazine (Repoise, Tyrylen) is a typical antipsychotic of the phenothiazine class. It was approved in 1967, and possibly discontinued in the 1980s.

Synthesis

Patent:

2-Butyrylphenothiazine (1) is the requisite starting material for carrying out the procedure. It is prepared in a manner that is synonymous with the method used in the propiomazine and propiopromazine already discussed. The 1-(γ-chloropropyl)-4-methylpiperazine (2) is prepared in the conventional way from alkylating 1-methylpiperazine and 1-Bromo-3-chloropropane. Sodamide is used to extract the 10-H thereby facilitating the nucleophilic substitution reaction. And completing the instalment of the sidechain.

See also

References

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ "Evaluation of a new antipsychotic agent. Butaperazine maleate (repoise maleate)". JAMA. 206 (10): 2307–8. December 1968. doi:10.1001/jama.206.10.2307. PMID 4386884.
  3. ^ Dr Ulrich Hoerlein, Dr Klaus-Heinz Risse, Dr Wolfgang Wirth, DE 1120451  (1961 to Bayer Ag).
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